Research Interests

The members of the ORFEO-CINQA team have vide experience in the study of processes involving organotransition metal complexes, from synthesis to catalysis or to the study of fundamental reaction mechanisms. Currently they are interested in applying their expertise to the following research lines:

  1. Hydrogen: production, storage and transport.
  2. Functionalization and transformation of hydrocarbons.
  3. Fixation and use of CO2.
  4. Generation of biofunctional structures based on transition metals.
  5. Generation of new functional materials based on macromolecules and composites.


1. M. Frutos, M. A. Ortuño, A. Lledós, A. Viso, R. Fernández de la Pradilla, M. C. De la Torre, M. A. Sierra, H. Gornitzka, C. Hemmert

Desulfinylation of Ag(I) Sulfinyl Mesoionic Carbenes: Preparation of C-Unsubstituted Au(I)–1,2,3-Triazole Carbene Complexes

Org. Lett., 2017, 19, 822–825

2. L. Álvarez-Rodríguez, J. A. Cabeza, P. García-Álvarez, M. Gómez-Gallego, A. D. Merinero, M. A. Sierra

First Insertions of Carbene Ligands into Ge-N and Si-N Bonds

Chem. Eur. J., 2017, 23, 4287–4291

3. S. Ruiz-Botella, P. Vidossich, G. Ujaque, E. Peris, P. Beer

Tripodal halogen bonding iodo-azolium receptors for anion recognition

RSC Advances, 2017, 7, 11253-11258

4. Leon, F.; González-Liste, P.; García-Garrido, S. E.; Arribas, I.; Rubio, M.; Cedieron, V.; Pizano, A.

Broad Scope Synthesis of Ester Precursors of Nonfunctionalized Chiral Alcohols Based on the Asymmetric Hydrogenation of α,β-Dialkyl , α,β-Diaryl , and α Alkyl-β-aryl-vinyl Esters

J. Org. Chem. 2017, 82, 5852−5867

5. Esteruelas, M. A.; Fernández, I.; García-Yebra, C.; Martín, J.; Oñate, E.

Elongated σ-Borane versus σ-Borane in Pincer-POP-Osmium Complexes

Organometallics 2017, 36, 2298−2387

6. Selva, V.; Larrañaga, O.; Castelló, L. M.; Nájera, C.; Sansano, J. M.; De Cózar, A.

Diastereoselective [3 + 2] vs [4 + 2] Cycloadditions of Nitroprolinates with α,β-Unsaturated Aldehydes and Electrophilic Alkenes: An Example of Total Periselectivity

J. Org. Chem. 2017, 82, 6298−6312

7. Lahosa, A.; Soler, T.; Arrieta, A. ; Cossío, F. P.; Foubelo, F.; Yus, M.

Stereoselective Coupling of  N-tert-Butanesulfinyl aldimines and  β-Ketoacids: Access to  β-Aminoketones

J. Org. Chem. 2017, 82, 7481−7491

1. A. de Cózar, O. Larrañaga, F. M. Bickelhaupt, E. San Sebastián, E. Ortega-Carrasco, J.-D. Maréchal, A. Lledós, F. P. Cossío

New Insights into the Reactivity of Cisplatin with Free and Restrained Nucleophiles: Microsolvation Effects and Base Selectivity in Cisplatin-DNA Interactions

ChemPhysChem 2016, 17, 3932–3947

2. S. Izquierdo, S. Essafi, I. del Rosal, P. Vidossich, R. Pleixats, A. Vallribera, G. Ujaque, A. Lledós, A. Shafir

Acid Activation in Phenyliodine Dicarboxylates: Direct Observation, Structures, and Implications

J. Am. Chem. Soc. 2016, 138, 12747-12750

3. A. Cayuelas, O. Larrañaga, C. Nájera, J. M. Sansano, A. de Cózar, F. P. Cossío

Taniaphos·AgF-catalyzed enantioselective 1,3-dipolar cycloaddition of stabilized azomethine ylides derived from 2,2-dimethoxyacetaldehyde

Tetrahedron 2016, 72, 6043-6051.

4. M. A. Esteruelas, P. Nolis, M. Oliván, E. Oñate, A. Vallribera, A. Vélez

Ammonia-Borane Dehydrogenation Promoted by a Pincer-Square-Planar Rhodium(I)-Monohydride: A Stepwise Hydrogen Transfer from the Substrate to the Catalyst

Inorg. Chem. 2016, 55, 7176-7181

5. C. Cristóbal, L. L. Santos, R. Gutiérrez-González, E. Álvarez, M. Paneque, M. L. Poveda

Allylic C–H Activation of Olefins by a TpMe2IrIII Compound

Eur. J. Inorg. Chem. 2016, 2534-2542

6. M. Roselló-Merino, R. J. Rama, J. Díez, S. Conejero

Catalytic dehydrocoupling of amine-boranes and amines into diaminoboranes: isolation of a Pt(II), Shimoi-type, η1-BH complex

Chem. Commun. 2016, 52, 8389-8392

7. A. Cayuelas, R. Ortiz, C. Nájera, J. M. Sansano, O. Larrañaga, A. de Cózar, F. P. Cossío

Enantioselective Synthesis of Polysubstituted Spiro-nitroprolinates Mediated by a (R,R)Me-DuPhos·AgF-Catalyzed 1,3-Dipolar Cycloaddition

Org. Lett. 2016, 18, 2926-2929

8. C. Valderas, L. Casarrubios, A. Lledós, M. A. Ortuño, M. C. de la Torre, M. A. Sierra

Silver(I)-Catalyzed Addition of Phenols to Alkyne Cobalt Cluster Stabilized Carbocations

Chem. Eur. J. 2016, 22, 9015-9023

9. P. J. González-Liste, F. León, I. Arribas, M. Rubio, S. E. García-Garrido, V. Cadierno, A. Pizzano

Highly Stereoselective Synthesis and Hydrogenation of (Z)1-Alkyl-2-arylvinyl Acetates: a Wide Scope Procedure for the Preparation of Chiral Homobenzylic Esters

ACS Catal. 2016, 6, 3056-3060

10. M. L. Buil, J. J. F. Cardo, M. A. Esteruelas, I. Fernández, E. Oñate

An Entry to Stable Mixed Phosphine−Osmium−NHC Polyhydrides

Inorg. Chem. 2016, 55, 5062-5070

11. P. Sabater, F. Zapata, A. Caballero, I. Fernández, C. Ramirez de Arellano, P. Molina

2,4,5-Trimethylimidazolium Scaffold for Anion Recognition Receptors Acting Through Charge-Assisted Aliphatic and Aromatic C−H Interactions

J. Org. Chem. 201681, 3790-3798

12. G. M. Chu, A. Guerrero-Martínez, C. Ramírez de Arellano, I. Fernández, M. A. Sierra

Remote Control by π‑Conjugation of the Emissive Properties of Fischer Carbene-BODIPY Dyads

Inorg. Chem. 2016, 55, 2737-2747

13. G. M. Chu, I. Fernández, A. Guerrero-Martínez, C. Ramírez de Arellano, M. A. Sierra

Fluorescence Quenching in BODIPYs Having Ir- and Rh-Tethered Complexes

Eur. J. Inorg. Chem. 2016, 844-852

14. J. A. Castro-Osma, A. Lara-Sánchez, A. Otero, A. M. Rodríguez, M. C. de la Torre, M. A. Sierra

An Efficient and Tunable Route to Bis(1,2,3-triazol-1-yl)methane-Based Nitrogen Compounds

Eur. J. Org. Chem. 2016, 682-687

15. J. Francos, P. J. González-Liste, L. Menéndez-Rodríguez, P. Crochet, V. Cadierno, J. Borge, A. Antiñolo, R. Fernández-Galán, F. Carrillo-Hermosilla

Half-Sandwich Guanidinate–Osmium(II) Complexes: Synthesis and Application in the Selective Dehydration of Aldoximes

Eur. J. Inorg. Chem. 2016, 393-402

16. N. Casanova, M. A. Esteruelas, M. Gulías, C. Larramona, J. L. Mascareñas, E. Oñate

Amide-Directed Formation of Five-Coordinate Osmium-Alkylidenes from Alkynes

Organometallics 2016, 35, 91-99

17. Ruiz-Botella, P. Vidossich, G. Ujaque, E. Peris

Rim, Side Arms and Cavity: Three Sites for the Recognition of Anions by Tetraazolium Resorcinarene Cavitands

Chem. Eur. J. 2016, 22, 15800-15806.

18. A. Sierra, A. D. Merinero, E. A. Giner, Mar Gómez-Gallego, C. Ramírez de Arellano

An Entry to Mixed NHC–Fischer Carbene Complexes and Zwitterionic Group 6 Metal Alkenyls

Chem. Eur. J. 2016, 22, 13521-13531

19. Rull, J. J. Jara, R. M. Sebastián, A. Vallribera, C. Nájera, J.-P. Majoral, A.-M. Caminade,

Recoverable Dendritic Phase-Transfer Catalysts that Contain (+)-Cinchonine-Derived Ammonium Salts

ChemCatChem. 2016, 8, 2049-2056

P. Ríos, J. Díez, J. López-Serrano, A. Rodríguez, S. Conejero

Cationic Platinum(II) σ-SiH Complexes in Carbon Dioxide Hydrosilation

Chem. Eur. J. 2016, 22, 16791-16795

1. J. Mancebo-Aracil, C. Nájera, L. M. Castelló, J. M. Sansano, O. Larrañaga, A. de Cózar, F. P. Cossío

Regio and diastereoselective multicomponent 1,3-dipolar cycloadditions between prolinate hydrochlorides, aldehydes and dipolarophiles for the direct synthesis of pyrrolizidines

Tetrahedron 2015, 71, 9645-9661

2. L. Casarrubios, M. A. Esteruelas, C. Larramona, J. G. Muntaner, E. Oñate, M. A. Sierra

2-Azetidinones as Precursors of Pincer Ligands: Preparation, Structure, and Spectroscopic Properties of CC′N-Osmium Complexes

Inorg. Chem. 2015, 54, 10998-11006

3. L. Casarrubios, M. A. Esteruelas, C. Larramona, A. Lledós, J. G. Muntaner, E. Oñate, M. A. Ortuño, M. A. Sierra

Mechanistic Insight into the Facilitation of β-Lactam Fragmentation through Metal Assistance: Mechanistic Insight

Chem. Eur. J. 2015, 21, 16781-16785

4. A. Álvarez-Pérez, C. González-Rodríguez, C. García-Yebra, J. A. Varela, E. Oñate, M. A. Esteruelas, C. Saá

Catalytic Cyclization of o-Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3-Benzazepines

Angew. Chem. Int. Ed. 2015, 54, 13357-13361

5. P. R. R. Costa, J. M. Sansano, U. Cossío, J. C. F. Barcellos, A. G. Dias, C. Nájera, A. Arrieta, A. de Cózar, F. P. Cossío

Synthesis of Chromen[4,3-b]pyrrolidines by Intramolecular 1,3-Dipolar Cycloadditions of Azomethine Ylides: An Experimental and Computational Assessment of the Origin of Stereocontrol

Eur. J. Org. Chem. 2015, 4689-4698

6. T. Bolaño, M. A. Esteruelas, M. P. Gay, E. Oñate, I. M. Pastor, M. Yus

An Acyl-NHC Osmium Cooperative System: Coordination of Small Molecules and Heterolytic B−H and O−H Bond Activation

Organometallics 2015, 34, 3902-3908

7. L. Menéndez-Rodríguez, E. Tomás-Mendivil, J. Francos, P. Crochet, V. Cadierno, A. Antiñolo, R. Fernández-Galán, F. Carrillo-Hermosilla

Reactivity of the Dimer [{RuCl(μ-Cl)(η33C10H16)}2] (C10H16 = 2,7-Dimethylocta-2,6-diene-1,8-diyl) toward Guanidines: Access to Ruthenium(IV) and Ruthenium(II) Guanidinate Complexes

Organometallics 2015, 34, 2796-2809

8. L. Menéndez-Rodríguez, E. Tomás-Mendivil, J. Francos, C. Nájera, P. Crochet, V. Cadierno

Palladium complexes with a phosphino-oxime ligand: synthesis, structure and applications to the catalytic rearrangement and dehydration of aldoximes

Catal. Sci. Technol. 2015, 5, 3754-3761

9. B. Eguillor, M. A. Esteruelas, I. Fernández, M. Gómez-Gallego, A. Lledós, M. Martín-Ortiz, M. Oliván, E. Oñate, M. A. Sierra

Azole Assisted C−H Bond Activation Promoted by an Osmium-Polyhydride: Discerning between N and NH

Organometallics 2015, 34, 1898-1910

10. E. A. Giner, A. Santiago, M. Gómez-Gallego, C. Ramírez de Arellano, R. C. Poulten, M. K. Whittlesey, M. A. Sierra

Mono- and Bimetallic Zwitterionic Chromium(0) and Tungsten(0) Allenyls

Inorg. Chem. 2015, 54, 5450-5461

11. L. M. Castelló, C. Nájera, J. M. Sansano, O. Larrañaga, A. de Cózar, F. P. Cossío

Enantioselective synthesis of exo-4-Nitroprolinates from Nitroalkenes and Azomethyne Ylides Catalyzed by Chiral Phosphoramidite·Silver of Copper Complexes

Synthesis 2015, 47, 934-943

12. T. Bolaño, M. A. Esteruelas, I. Fernández, E. Oñate, A. Palacios, J.-Y. Tsai, C. Xia

Osmium(II)−Bis(dihydrogen) Complexes Containing Caryl,CNHC−Chelate Ligands: Preparation, Bonding Situation, and Acidity

Organometallics 2015, 34, 778−789

13. M. L. Buil, J. J. F. Cardo, M. A. Esteruelas, I. Fernández, E. Oñate

Hydroboration and Hydrogenation of an Osmium−Carbon Triple Bond: Osmium Chemistry of a Bis-σ-Borane

Organometallics 2015, 34, 547−550

14. A. E. Roa, J. Campos, M. Paneque, V. Salazar, A. Otero, A. Lara-Sánchez, A. M. Rodríguez, I. López-Solera, M. V. Gómez

Synthesis of new heteroscorpionate iridium(I) and iridium(III) complexes

Dalton Trans. 2015, 44, 6987-6998

15. G. Retamosa, A. de Cózar, M. Sánchez, J. I. Miranda, J. M. Sansano, L. M. Castelló, C. Nájera, A. I. Jiménez, F. J. Sayago, C. Cativiela F. P. Cossío

Remote Substituent Effects on the Stereoselectivity and Organocatalytic Activity of Densely Substituted Unnatural Proline Esters in Aldol Reactions

Eur. J. Org. Chem. 2015, 2503-2516

16. Menendez-Pedregal, M. Vaquero, E. Lastra, P. Gamasa, A. Pizzano,

Highly Enantioselective Hydrogenation of N-Aryl Imines Derived from Acetophenones by Using Ru-Pybox Complexes under Hydrogenation or Transfer Hydrogenation Conditions in Isopropanol

Chem. Eur. J. 2015, 21, 549-553.